Serotonin Agonists and Antagonists


 * 1) Describe the biosynthesis and metabolism of serotonin.
 * 2) Explain the mechanism of action of triptans in the treatment of migraines.
 * 3) Describe the adverse effects and contraindications of triptans.
 * 4) Describe triptan SAR, recognize structures triptans and describe associated clinical features.
 * 5) Explain the proposed indication for use and mechanism of action of 5-HT1F agonists.
 * 6) Explain the mechanism of action of 5-HT3 receptor antagonists in the management of chemotherapy induced and post-operative nausea and vomiting.
 * 7) Describe the three necessary components for 5-HT3 affinity and recognize the structures of the 5-HT3 receptor antagonists.
 * 8) Describe the structure of the active metabolite of dolasetron.